Medications such as ibuprofen, aspirin, and acetaminophen are common non-steroidal pain therapies.
They are also used for fevers and in higher doses to combat inflammation. Recent research from Temitayo Olumakinwa Obanla at North Carolina Agricultural and Technical State University explored whether these drugs interfere with viability and functionality of probiotics.
The study looked at effect on Bifidobacterium strains. Species considered were: B. breve, B. longum, B. infantis, B. adolescentis, and B. bifidium. One tablet of Aleve, Aspirin, and Tylenol was dissolved and then inoculated with 1mL of probiotic dilutions. After incubation for 24 hours, survival rates as well as other biomarkers of bifidobacterium function were assessed.
- Decrease in bifidobacteria population.
- β-Galactosidase was reduced by aspirin and acetaminophen.
- Significant effect on death rate of bifidobacteria, adhesion to mucosal layer, enzyme activity, and protein expression of bifidobacteria
In addition, all NSAIDS can damage the tissue of the gastrointestinal tract. Damage can occur anywhere, from mouth to anus.
Rethinking their liberal use is recommended.