{"id":2219,"date":"2016-12-04T23:39:06","date_gmt":"2016-12-05T04:39:06","guid":{"rendered":"http:\/\/ipa.local\/?p=2219"},"modified":"2018-07-05T11:04:38","modified_gmt":"2018-07-05T16:04:38","slug":"old-age-altered-microbiomes-can-lead-disease","status":"publish","type":"post","link":"https:\/\/internationalprobiotics.org\/home\/old-age-altered-microbiomes-can-lead-disease\/","title":{"rendered":"In Old Age, Our Altered Microbiomes Can Lead to Disease"},"content":{"rendered":"<p>The <strong>aging microbiome<\/strong> bumps into challenges its younger self may not have: chronic diseases, exposure to group living, multiple medications and changes in dentition and swallowing that disrupt diet.<br \/>\nYale Medical School Professor <a href=\"https:\/\/medicine.yale.edu\/intmed\/infdis\/people\/vincent_quagliarello-1.profile\">Vincent Quagliarello, MD<\/a> discussed the vagaries of the microbiome in older adults recently at the <a href=\"http:\/\/harvardprobioticssymposium.org\/\">Harvard Probiotics Symposium<\/a>.<\/p>\n<p>There are <em>\u201ca myriad of clinical changes, including a basal proinflammatory state (inflamm-aging), that directly interface with the microbiota of older adults and enhance susceptibility to disease accompany aging,\u201d<\/em> according to Quagliarello.<\/p>\n<p><strong>\u00a0A little background<\/strong>: <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4406803\/\">inflamm-aging <\/a>is caused by the high concentrations of <strong>reactants<\/strong> and <strong>cytokines<\/strong> which leads to impaired immune responses and is implicated in age-related problems including atherosclerosis and neurodegeneration.<\/p>\n<p>The issues facing the elderly, Quagliarello said, affect the microbiome and can lead to chronic illness. One example is the <em>Clostridium difficile (C. difficile)<\/em> infection. Here\u2019s how it works: antibiotic exposure depletes gut resistance to harmful bacteria such as <em>C. difficile,<\/em> which in turn can become impervious to antibiotic treatments. It\u2019s obviously a vicious cycle with few good outcomes.\u00a0 Fortunately, a solution emerged: <strong>fecal transplant<\/strong> is proving to be revolutionary in normalizing a nasty and often fatal infestation.<br \/>\nThe microbiota have been implicated in other physical conditions that affect older adults, detailed in <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4406803\/\">\u201cThe microbiota and microbiome in aging: potential implications in health and age-related diseases,\u201d<\/a> which appeared in the Journal of American Geriatric Society in April of 2015 by Heidi Zapata and Vincent Quagliarello.<\/p>\n<ul>\n<li><strong>Vulvovaginal atrophy<\/strong>, common in elderly women, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18701205\">may benefit from oral lactobacilli<\/a>, a bacteria depleted in the condition.<\/li>\n<li>Microbiota of <strong>colon cancers<\/strong> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23954159\">display more Fusobacterium species<\/a> than non-cancerous tissue. In addition, stool samples in colon cancer patients <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21850056\">reveal fewer butyrate-producing bacteria and increased pathogens<\/a>. This inflammatory condition may contribute to tumors.<\/li>\n<li>The microbiota may also play a <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16531752\">role in<strong> cardiovascular disease<\/strong><\/a> among older adults.<\/li>\n<li>Periodontal-disease causing bacteria in the oral cavity are linked to both <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20453665\">hypertension<\/a> and <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15699278\">carotid thickening<\/a>.<\/li>\n<\/ul>\n<p><strong>Thus, manipulation of the microbiota is showing promise as novel strategy to influence age-related problems.<\/strong><br \/>\nIn his talk, Dr. Quagliarello related how <a href=\"http:\/\/eldermet.ucc.ie\/\">ELDERMET <\/a>and the <a href=\"http:\/\/www.eufic.org\/article\/en\/page\/FTARCHIVE\/artid\/eu_project_nu-age\">NU-AGE<\/a> project are moving the research on gut microbiome and the elderly forward.\u00a0 Funded by the Irish government, the ELDERMET project is a coalition of scientists at University College Cork in Ireland. Find many microbiome-associated research articles at this <a href=\"http:\/\/eldermet.ucc.ie\/publications\/\">site<\/a>.<br \/>\nTheir work studies the relationship between diet, gut bacteria and health status in a large number of elderly Irish subjects.<\/p>\n<p>Results fed into a 5 year project, now ended, called <a href=\"http:\/\/www.eufic.org\/article\/en\/page\/FTARCHIVE\/artid\/eu_project_nu-age\">NU-AGE<\/a> which is <em>\u201ca large multidisciplinary consortium with 30 partners, from 16 EU countries, involving nutritionists, biogerontologists, immunologists and molecular biologists from the most prestigious institutions in Europe.\u201d<\/em><\/p>\n<p><strong>Interesting findings from ELDERMET include:<\/strong><\/p>\n<ul>\n<li>\u00a0Long-term residential subjects had a higher proportion of gut <em>Bacteroidetes<\/em>; those dwelling in the community had a higher proportion of <em>Firmicutes.<\/em><\/li>\n<li>\u00a0Those differences appeared over a one-year period.<\/li>\n<li>\u00a0Microbiota were more diverse with those eating a low fat\/high fiber diet than a moderate fat\/low fiber or a high fat\/low fiber diet.<\/li>\n<li>\u00a0Inflammation biomarkers were higher in residential vs. community dwellers.<\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4406803\/\">Researchers <\/a>are also seeking links between our microbes and other common conditions in the elderly including pneumonia, urinary tract infection, and other cancers.\u00a0 The best is yet to come.<!--more--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The aging microbiome bumps into challenges its younger self may not have: chronic diseases, exposure to group living, multiple medications and changes in dentition and swallowing that disrupt diet. Yale Medical School Professor Vincent Quagliarello, MD discussed the vagaries of the microbiome in older adults recently at the Harvard Probiotics Symposium. There are \u201ca myriad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2222,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_eb_attr":"","_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[367,365],"tags":[131],"_links":{"self":[{"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/posts\/2219"}],"collection":[{"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/comments?post=2219"}],"version-history":[{"count":1,"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/posts\/2219\/revisions"}],"predecessor-version":[{"id":4744,"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/posts\/2219\/revisions\/4744"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/media\/2222"}],"wp:attachment":[{"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/media?parent=2219"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/categories?post=2219"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/tags?post=2219"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}