{"id":5760,"date":"2019-10-23T12:29:14","date_gmt":"2019-10-23T17:29:14","guid":{"rendered":"https:\/\/internationalprobiotics.org\/?p=5760"},"modified":"2020-02-19T17:36:13","modified_gmt":"2020-02-19T22:36:13","slug":"for-better-sleep-turn-to-microbes","status":"publish","type":"post","link":"https:\/\/internationalprobiotics.org\/home\/for-better-sleep-turn-to-microbes\/","title":{"rendered":"For Better Sleep, Turn to Microbes"},"content":{"rendered":"\n<p>When humans sleep poorly, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28579842\">health suffers<\/a>. Mental performance declines as  risks of diseases including cancer, diabetes and Alzheimer\u2019s rise.<\/p>\n\n\n\n<p>Thus the quest for a good night\u2019s sleep brooks no limits; ergonomic mattresses, white noise machines and powerful drugs are just a few if not always fruitful fixes. &nbsp;<\/p>\n\n\n\n<p>Growing <a href=\"https:\/\/internationalprobiotics.org\/sleeping-beauty\/\">evidence<\/a> suggests that the gut microbiome can influence sleep quality. Previous studies that have examined sleep deprivation and the human gut microbiome have yielded conflicting results. Now <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0222394\">new techniques<\/a> may offer up further clues.<\/p>\n\n\n\n<p>Researchers from Nova Southeastern University in Fort Lauderdale, Florida employed <a href=\"https:\/\/www.uptodate.com\/contents\/actigraphy-in-the-evaluation-of-sleep-disorders\">actigraphy<\/a> (noninvasive accelerometer) to quantify sleep measures along with gut microbiome sampling to determine correlations. They also measured immune system biomarkers and carried out a neurobehavioral assessment. Forty males participated in the study. <\/p>\n\n\n\n<p><a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0222394\">Gut microbiome diversity is associated with sleep physiology in humans<\/a> appeared in PloS October 2019.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Major findings <\/h3>\n\n\n\n<ul><li>Total microbiome <strong>diversity<\/strong> was positively correlated with increased sleep efficiency and total sleep time. <\/li><li>Total microbiome <strong>diversity<\/strong> was negatively correlated with waking after sleep onset.<\/li><li>Positive correlations existed between total microbiome diversity and <strong>interleukin-6<\/strong>, a cytokine previously noted for its effects on sleep. <\/li><li>Microbiome analysis revealed richness of <em>Bacteroidetes<\/em> and <em>Firmicutes<\/em> were positively correlated with sleep efficiency, interleukin-6 concentrations and abstract thinking. Note: members of these phyla may <a href=\"https:\/\/www.mdpi.com\/2076-2607\/7\/2\/41\">modulate circadian rhythm<\/a> which may impact sleep quality. <\/li><li>Several taxa (<em>Lachnospiraceae<\/em>, <em>Corynebacterium<\/em>, and <em>Blautia<\/em>) were negatively correlated with sleep measures. <\/li><\/ul>\n\n\n\n<p>As only\nmales were included, sleep loss effects on the microbiome in women aren\u2019t\ncertain. Nevertheless the researchers surmised that the effects may be greater\nas <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12768650\">consequences of lost\nsleep accumulate more rapidly in women<\/a> than men.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Conclusions<\/h3>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>&nbsp;\u201c\u2026 <em>our results show a novel association between sleep health and gut microbiome diversity. Moreover, we found that IL-6 is as an important player in the sleep-gut microbiome relationship. Finally, we identified several specific phyla and taxa that are related to sleep health, which holds the promise for improved sleep via manipulation of the gut microbiome.\u201d<\/em><\/p><cite>Smith RP, Easson C, Lyle SM, Kapoor R, Donnelly CP, Davidson EJ, et al. (2019) Gut microbiome diversity is associated with sleep physiology in humans. PLoS ONE 14(10): e0222394. https:\/\/doi.org\/10.1371\/journal.pone.0222394<\/cite><\/blockquote>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>When humans sleep poorly, health suffers. Mental performance declines as risks of diseases including cancer, diabetes and Alzheimer\u2019s rise. Thus the quest for a good night\u2019s sleep brooks no limits; ergonomic mattresses, white noise machines and powerful drugs are just a few if not always fruitful fixes. &nbsp; Growing evidence suggests that the gut microbiome [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":5761,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_eb_attr":"","_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[1,369],"tags":[516,513],"_links":{"self":[{"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/posts\/5760"}],"collection":[{"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/comments?post=5760"}],"version-history":[{"count":3,"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/posts\/5760\/revisions"}],"predecessor-version":[{"id":5769,"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/posts\/5760\/revisions\/5769"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/media\/5761"}],"wp:attachment":[{"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/media?parent=5760"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/categories?post=5760"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/internationalprobiotics.org\/home\/wp-json\/wp\/v2\/tags?post=5760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}