{"id":7784,"date":"2022-01-10T20:11:02","date_gmt":"2022-01-11T01:11:02","guid":{"rendered":"https:\/\/internationalprobiotics.org\/?p=7784"},"modified":"2022-01-10T20:13:04","modified_gmt":"2022-01-11T01:13:04","slug":"can-probiotics-reduce-harms-of-phthalates","status":"publish","type":"post","link":"https:\/\/internationalprobiotics.org\/home\/can-probiotics-reduce-harms-of-phthalates\/","title":{"rendered":"Can Probiotics Reduce Harms of Phthalates?"},"content":{"rendered":"\n
First introduced in the 1920s, phthalates are commercial chemicals used in a vast array of consumer products: plastic and vinyl, medical supplies, flooring, wall coverings, cosmetics, personal care products and toys. Their usefulness in industry <\/a>is undeniable but researchers have observed harmful effects on endocrine<\/a>, metabolic<\/a> and neurological<\/a> systems in the human body. Although elimination or substitution of phthalates by governments or voluntary action<\/a> is underway, the continued ubiquity of phthalates and their concomitant harms remains a serious global public health concern.<\/p>\n\n\n\n The gut microbiota is often the first line of defense<\/a> against many toxins, which may enter through food and water and may have the potential to disturb the microflora balance. Other exposure routes are through the skin and lungs.<\/p>\n\n\n\n Xenobiotics<\/a> (Greek, xenos “foreign”; bios “life”) are chemical substances not normally present in or produced by the environment of living organisms. In addition to phthalates, numerous other chemicals of concern exist in the environment due to industrialization; although they will not be discussed here, these include persistent organic pollutants (POPs), and heavy metals, among others. Mounting evidence indicates that chronic xenobiotics exposure negatively affects human health<\/a>, notably via inflammation, oxidative stress, and disruption of gut microflora composition and metabolite synthesis.<\/p>\n\n\n\n According to a recent review<\/a>, some probiotic microorganisms may be able to protect against many specific xenobiotics through various mechanisms: <\/p>\n\n\n\n Restoring the functions of the gut microbial population and the integrity of the gut epithelial barrier may be an effective approach to fighting the detrimental effects of environmental pollutants. <\/p>\n\n\n\n However, scientific evidence on phthalates in that regard is scant, relying primarily on animal models or in vitro studies. Yet, the potential for benefit is becoming more promising as research progresses.<\/p>\n\n\n\n Di-2-ethylhexyl phthalate (DEHP) is one of the commonly detected phthalate types in the environment. DEHP has a serious disruptive effect on reproductive health. In a 2019 study<\/a> using DEHP- exposed mice, a strain of Lactobacillus plantarum<\/em> (currently renamed Lactiplantibacillus plantarum<\/em><\/a>) improved male reproductive system functions by increasing serum testosterone hormone levels, improved the quality of semen, and ameliorated gonad development defects.<\/p>\n\n\n\n Detoxification of another phthalate compound (Di-n-butyl phthalate) by an inactivated strain of Lactobacillus acidophilus<\/em> was observed in an in vitro<\/em> cell model as reported in a 2021 publication<\/a>.<\/p>\n\n\n\n The following two studies combine phthalates and bisphenol A, ostensibly because of their uses in commercial water bottles<\/a>:<\/p>\n\n\n\n In a few animal studies, some probiotics appeared to mitigate the impact of specific phthalates. However, this field of research is still in its infancy.<\/p>\n\n\n\n Yet, given the overarching role of a healthy microbiome on human health, the potential use of probiotics to support microbiome health against phthalates appears to be worth further investigation.<\/p>\n\n\n\n Note<\/strong>: Phthalates are only one class among the many environmental toxins that can be harmful. In the coming months, we will summarize available research exploring the role of probiotics in protecting against other xenobiotics, notably parabens, phenolic compounds, and pesticides.<\/p>\n\n\n\n Abdelsalam, Nehal Adel et al. \u201cToxicomicrobiomics: The Human Microbiome vs. Pharmaceutical, Dietary, and Environmental Xenobiotics<\/a>.\u201d Frontiers in pharmacology<\/em> vol. 11 390. 16 Apr. 2020, doi:10.3389\/fphar.2020.00390<\/p>\n\n\n\n Barali\u0107, Katarina et al. \u201cIntegrating in silico with in vivo approach to investigate phthalate and bisphenol A mixture-linked asthma development: Positive probiotic intervention.<\/a>\u201d Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association<\/em> vol. 158 (2021): 112671. doi:10.1016\/j.fct.2021.112671<\/p>\n\n\n\n Barali\u0107, Katarina et al. \u201cMulti-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats<\/a>.\u201d Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association<\/em> vol. 143 (2020): 111540. doi:10.1016\/j.fct.2020.111540<\/p>\n\n\n\n Chen, Lianguo. \u201cGut Microbiota Manipulation to Mitigate the Detrimental Effects of Environmental Pollutants<\/a>.\u201d Toxics<\/em> vol. 9,6 127. 1 Jun. 2021, doi:10.3390\/toxics9060127<\/p>\n\n\n\n da Silva Costa, Rouse et al. \u201cPotential risk of BPA and phthalates in commercial water bottles: a minireview<\/a>.\u201d Journal of water and health<\/em> vol. 19,3 (2021): 411-435. doi:10.2166\/wh.2021.202<\/p>\n\n\n\n Engel, Stephanie M et al. \u201cNeurotoxicity of Ortho-Phthalates: Recommendations for Critical Policy Reforms to Protect Brain Development in Children<\/a>.\u201d American journal of public health<\/em> vol. 111,4 (2021): 687-695. doi:10.2105\/AJPH.2020.306014<\/p>\n\n\n\n Haverinen, Elsi et al. \u201cMetabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects<\/a>.\u201d International journal of environmental research and public health<\/em> vol. 18,24 13047. 10 Dec. 2021, doi:10.3390\/ijerph182413047<\/p>\n\n\n\n \u015arednicka, Paulina et al. \u201cProbiotics as a biological detoxification tool of food chemical contamination: A review<\/a>.\u201d Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association<\/em> vol. 153 (2021): 112306. doi:10.1016\/j.fct.2021.112306<\/p>\n\n\n\n Tian, Xiaozhu et al. \u201cLactobacillus plantarum<\/em> TW1-1 Alleviates Diethylhexylphthalate-Induced Testicular Damage in Mice by Modulating Gut Microbiota and Decreasing Inflammation<\/a>.\u201d Frontiers in cellular and infection microbiology<\/em> vol. 9 221. 26 Jun. 2019, doi:10.3389\/fcimb.2019.00221<\/p>\n\n\n\nXenobiotics<\/strong><\/h3>\n\n\n\n
Probiotics and phthalates<\/strong><\/h3>\n\n\n\n
Takeaway<\/strong> on phthalates<\/strong><\/h3>\n\n\n\n
Key references<\/strong><\/h3>\n\n\n\n