Keystone: Microbiome in Health and Disease

IPA AdminClinical Corner

by Dr. Matthew A. Roberts, Ph.D., MBA,  Chief Scientific Officer – KGK Science USA   The human microbiota is a complex ecosystem living with its host and is responsive to the human condition capturing information on lifestyle, exposure to environmental factors, and our association with other humans as well as pets. We recently attended the Microbiome in Health and Disease … Read More

Probiotics: A No-Brainer for Brain Health

IPA AdminClinical Corner, Market Trends

anxiety

Drugs target serotonin to reduce depression and other mood disorders. Could probiotics do the same, given that the microbiome is one smooth operator in gut-brain signaling?[i] Researchers Caroline J. K. Wallace and Roumen Milev of Queens University in Ontario asked the same in “The effects of probiotics on depressive symptoms in humans: a systematic review” which appeared in Annals of General Psychiatry in February, 2017. … Read More

How Gray are your Microbes?

IPA AdminClinical Corner, Market Trends

elderly

Is aging a disease? Some in the ranks of research think it may be so. Others stick to the idea that aging begins after the snip of the umbilical cord, the intrinsic nature of the mortal beast. Michael S. Lustgarten of Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in Boston has written a provocative piece titled … Read More

For Stiff Joints, Microbes Matter

IPA AdminClinical Corner, Market Trends, Microbiome Environment

Baby boomers are finding the spirit is often willing, but knees—not so much. Sore and stiff joints seem to arrive just when you line up for your $10 Senior Pass at the U.S. National Parks. First, know there are two main types of arthritis: Rheumatoid arthritis (RA) is immunity gone rogue, an autoimmune disorder causing inflammation of joints and other … Read More

For True Detectives, Microbes Leave Fingerprints

IPA AdminClinical Corner, Microbiome Environment

Fingerprints have led to many a criminal’s downfall. Tips of our digits leave evidence for a very long time helping detectives link the perp to the crime. Alas, gloves are now de rigeur for all but the clumsiest. Now forensic scientists may have a new tool for their investigations: microbes. As explored in IPA’s “Cloudy with a Chance of Microbes” … Read More

Probiotics May Thwart Mental Changes in HIV

IPA AdminClinical Corner, Market Trends

Infection with human immunodeficiency virus (HIV) brings numerous harms, not least a dysbiosis leading to: microbial translocation chronic immune activation changes in tryptophan metabolism These toxic effects are felt by the central nervous system (CNS) and are poorly understood. Concerning tryptophan–an essential (not made by the body) amino acid provided by diet– an enzyme indolamine-2,3-dioxygenase (IDO) breaks it down into … Read More

Probiotics: A Look at Dose and Response

IPA AdminClinical Corner, Market Trends

probiotics

As of 2001, probiotics have been defined by the World Health Organization’s (WHO) as “live micro-organisms which, when administered in adequate amounts, confer a health benefit on the host.” The health benefit of probiotics has seen its reach extend beyond the gut and across organs and metabolic systems. Still, little is known about what is actually an “adequate amount.” Fortunately, … Read More

Bacteriocins: Time To Harness The Power?

IPA AdminClinical Corner, Market Trends

bacteriocins

In a 2016 article Bacteriocin production: a relatively unharnessed probiotic trait? a group of researchers in Cork, Ireland led by James W. Hegarty, are making a case for bacteriocins. What are bacteriocins? Peptides produced by bacteria that can act against other similar bacteria; the producers remain immune.  High in diversity: size, structure, mechanisms of action. Receptors are a few ways they … Read More

Pancreatic Cancer: Possible Role for Probiotics

IPA AdminClinical Corner, Market Trends

probiotics

Pancreatic cancer is a killer. In spite of advances in garnering its mechanism, the same cannot be said for treating this most fatal of cancers. Researchers are looking to the microbiome. Changes in diet, infection or lifestyle may disturb the normal symbiotic karma between host and the microbiota leading to cancer in the pancreas. As outlined by International Probiotic Association … Read More

In Old Age, Our Altered Microbiomes Can Lead to Disease

IPA AdminClinical Corner, Market Trends

arthritis

The aging microbiome bumps into challenges its younger self may not have: chronic diseases, exposure to group living, multiple medications and changes in dentition and swallowing that disrupt diet. Yale Medical School Professor Vincent Quagliarello, MD discussed the vagaries of the microbiome in older adults recently at the Harvard Probiotics Symposium. There are “a myriad of clinical changes, including a … Read More